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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 420250.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Contribution of Hippocampal and Extra−Hippocampal
NR2B−Containing NMDA Receptors to Performance
on Spatial Learning Tasks
Translation of Title:Contribution of Hippocampal and Extra−Hippocampal
NR2B−Containing NMDA Receptors to Performance
on Spatial Learning Tasks
Authors:von Engelhardt, Jakob; Doganci, Beril; Jensen, Vidar; Hvalby, Øivind; Göngrich, Christina; Taylor, Amy; Barkus, Chris; Sanderson, David J.; Rawlins, J. Nicholas P.; Seeburg, Peter H.; Bannerman, David M.; Monyer, Hannah
Language:English
Date of Publication (YYYY-MM-DD):2008-12-10
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:60
Issue / Number:5
Start Page:846
End Page:860
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Controversy revolves around the differential contribution of NR2A− and NR2B−containing NMDA receptors, which coexist in principal forebrain neurons, to synaptic plasticity and learning in the adult brain. Here, we report genetically modified mice in which the NR2B subunit is selectively ablated in principal neurons of the entire postnatal forebrain or only the hippocampus. NR2B ablation resulted in smaller NMDA receptor−mediated EPSCs with accelerated decay kinetics, as recorded in CA1 pyramidal cells. CA3−to−CA1 field LTP remained largely unaltered, although a pairing protocol revealed decreased NMDA receptor−mediated charge transfer and reduced cellular LTP. Mice lacking NR2B in the forebrain were impaired on a range of memory tasks, presenting both spatial and nonspatial phenotypes. In contrast, hippocampus−specific NR2B ablation spared hippocampus−dependent, hidden−platform water maze performance but induced a selective, short−term, spatial working memory deficit for recently visited places. Thus, both hippocampal and extra−hippocampal NR2B containing NMDA receptors critically contribute to spatial performance.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI f�r medizinische Forschung/Abteilung Molekulare Neurobiologie
External Affiliations:Department of Clinical Neurobiology, University of Heidelberg, D−69120 Heidelberg, Germany; Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, N−0317 Oslo, Norway; Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
Identifiers:LOCALID:7371
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
DOI:10.1016%2Fj.neuron.2008.09.039
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