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          Institute: MPI für medizinische Forschung     Collection: Max-Planck-Forschungsgruppe Neurophysiologie des Verhaltens (Andreas T. Schaefer)     Display Documents



ID: 420270.0, MPI für medizinische Forschung / Max-Planck-Forschungsgruppe Neurophysiologie des Verhaltens (Andreas T. Schaefer)
The Contribution of Single Synapses to Sensory Representation in Vivo
Translation of Title:The Contribution of Single Synapses to Sensory Representation in Vivo
Authors:Arenz, Alexander; Silver, Angus; Schaefer, Andreas T.; Margrie, Troy W.
Language:English
Date of Publication (YYYY-MM-DD):2008-08-15
Title of Journal:Science
Journal Abbrev.:Science
Volume:321
Issue / Number:5891
Start Page:977
End Page:980
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The extent to which synaptic activity can signal a sensory stimulus limits the information available to a neuron. We determined the contribution of individual synapses to sensory representation by recording excitatory postsynaptic currents (EPSCs) in cerebellar granule cells during a time−varying, quantifiable vestibular stimulus. Vestibular−sensitive synapses faithfully reported direction and velocity, rather than position or acceleration of whole−body motion, via bidirectional modulation of EPSC frequency. The lack of short−term synaptic dynamics ensured a highly linear relationship between velocity and charge transfer, and as few as 100 synapses provided resolution approaching psychophysical limits. This indicates that highly accurate stimulus representation can be achieved by small networks and even within single neurons.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI f�r medizinische Forschung/Nachwuchsgruppe Neurophysiologie des Verhaltens
MPI f�r medizinische Forschung/Abteilung Zellphysiologie
Identifiers:LOCALID:7297
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcgi%2Freprint%2F...
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcgi%2Fcontent%2F...
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcgi%2Fcontent%2F...
DOI:10.1126%2Fscience.1158391
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