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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents

ID: 428404.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis
Authors:Gensch, N.; Borchardt, T.; Schneider, A.; Riethmacher, D.; Braun, T.
Date of Publication (YYYY-MM-DD):2008
Title of Journal:Development
Issue / Number:9
Start Page:1597
End Page:1604
Audience:Not Specified
Abstract / Description:The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis. Here, we demonstrate by conditional cell ablation in mice that Myf5 determines a distinct myogenic cell population, which also contains some Myod1-positive cells. Ablation of this lineage uncovers the presence of a second autonomous myogenic lineage, which superseded Myf5-dependent myogenic cells and expressed Myod1. By contrast, ablation of myogenin-expressing cells erased virtually all differentiated muscle cells, indicating that some aspects of the myogenic program are shared by most skeletal muscle cells. We conclude that Myf5 and Myod1 define different cell lineages with distinct contributions to muscle precursor cells and differentiated myotubes. Individual myogenic cell lineages seem to substitute for each other within the developing embryo.
Free Keywords:Animals Animals, Newborn Bone and Bones/abnormalities Cell Differentiation/physiology Cell Lineage/*physiology Mesenchymal Stem Cells/cytology/physiology Mice Muscle Development/*physiology Muscle, Skeletal/abnormalities/cytology/embryology Mutation MyoD Protein/genetics/physiology Myoblasts, Skeletal/*cytology/physiology Myogenic Regulatory Factor 5/genetics/*physiology
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
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