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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents



ID: 428410.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation
Authors:Feller, J.; Schneider, A.; Schuster-Gossler, K.; Gossler, A.
Date of Publication (YYYY-MM-DD):2008
Title of Journal:Genes Dev
Volume:22
Issue / Number:16
Start Page:2166
End Page:2171
Audience:Not Specified
Abstract / Description:To test the significance of cyclic Notch activity for somite formation in mice, we analyzed embryos expressing activated Notch (NICD) throughout the presomitic mesoderm (PSM). Embryos expressing NICD formed up to 18 somites. Expression in the PSM of Hes7, Lfng, and Spry2 was no longer cyclic, whereas Axin2 was expressed dynamically. NICD expression led to caudalization of somites, and loss of Notch activity to their rostralization. Thus, segmentation and anterior-posterior somite patterning can be uncoupled, differential Notch signaling is not required to form segment borders, and Notch is unlikely to be the pacemaker of the segmentation clock.
Free Keywords:Animals Basic Helix-Loop-Helix Transcription Factors/physiology Biological Clocks/*physiology Body Patterning/*physiology Cytoskeletal Proteins/physiology Gene Expression Regulation, Developmental Glycosyltransferases/physiology In Situ Hybridization Membrane Proteins/physiology Mesoderm/cytology/*metabolism Mice Mice, Knockout Mice, Transgenic Receptors, Notch/*physiology *Signal Transduction Somites/cytology/*metabolism
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
Identifiers:URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=...
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