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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents

ID: 428422.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs
Authors:Alejandre-Alcazar, M. A.; Michiels-Corsten, M.; Vicencio, A. G.; Reiss, I.; Ryu, J.; de Krijger, R. R.; Haddad, G. G.; Tibboel, D.; Seeger, W.; Eickelberg, O.; Morty, R. E.
Date of Publication (YYYY-MM-DD):2008
Title of Journal:Dev Dyn
Issue / Number:1
Start Page:259
End Page:269
Audience:Not Specified
Abstract / Description:Although transforming growth factor-beta (TGF-beta) signaling negatively regulates branching morphogenesis in early lung development, few studies to date have addressed the role of this family of growth factors during late lung development. We describe here that the expression, tissue localization, and activity of components of the TGF-beta signaling machinery are dynamically regulated during late lung development in the mouse and human. Pronounced changes in the expression and localization of the TGF-beta receptors Acvrl1, Tgfbr1, Tgfbr2, Tgfbr3, and endoglin, and the intracellular messengers Smad2, Smad3, Smad4, Smad6, and Smad7 were noted as mouse and human lungs progressed through the canalicular, saccular, and alveolar stages of development. TGF-beta signaling, assessed by phosphorylation of Smad2, was detected in the vascular and airway smooth muscle, as well as the alveolar and airway epithelium throughout late lung development. These data suggest that active TGF-beta signaling is required for normal late lung development.
Free Keywords:Activin Receptors, Type I/genetics/metabolism/physiology Activin Receptors, Type II/genetics/metabolism/physiology Animals *Gene Expression Regulation, Developmental Humans Immunoblotting Immunohistochemistry Intracellular Signaling Peptides and Proteins/genetics/metabolism/physiology Lung/embryology/*metabolism Mice Mice, Inbred C57BL Protein-Serine-Threonine Kinases/genetics/metabolism/physiology Proteoglycans/genetics/metabolism/physiology Receptors, Transforming Growth Factor beta/genetics/metabolism/physiology Reverse Transcriptase Polymerase Chain Reaction Signal Transduction/*genetics/physiology Smad2 Protein/genetics/metabolism/physiology Smad3 Protein/genetics/metabolism/physiology Smad4 Protein/genetics/metabolism/physiology Smad6 Protein/genetics/metabolism/physiology Smad7 Protein/genetics/metabolism/physiology Transforming Growth Factor beta/*genetics/metabolism/physiology
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
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