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          Institute: MPI für Neurobiologie     Collection: Cellular and Systems Neurobiology     Display Documents



  history
ID: 432451.0, MPI für Neurobiologie / Cellular and Systems Neurobiology
Glycinergic Inhibition in the Hippocampus
Authors:Keck, T.; White, J. A.
Language:English
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Reviews in the Neurosciences
Journal Abbrev.:Rev. Neurosci.
Volume:20
Issue / Number:1
Start Page:13
End Page:22
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Glycine and GABA are the two main inhibitory neurotransmitters in the central nervous system (CNS). While GABA receptors in the hippocampus have been studied in great detail, the role of glycine receptors (GlyRs) in the hippocampus is less understood. Here we examine recent evidence suggesting that GlyRs are present and active throughout the hippocampus. Extracellular glycine levels are controlled through a combination of release and transport mechanisms, both of which, along with the GlyRs themselves, can be modulated by a number of factors. We discuss the role of GlyRs in suppressing excitation by decreasing postsynaptic membrane resistance in the hippocampus, as well as the contribution of GlyRs to both short- and long-term plasticity.
Free Keywords:glycine receptors; hippocampus; GlyT1; GlyT2; short term plasticity; long term plasticity
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Cellular and Systems Neurobiology (Bonhoeffer)
External Affiliations:[White, John A.] Univ Utah, Dept Bioengn, Inst Brain, Salt Lake City, UT 84112 USA.
Identifiers:ISI:000265903400002 [ID No:1]
ISSN:0334-1763 [ID No:2]
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