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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents



  history
ID: 432452.0, MPI für Neurobiologie / Neuroimmunology
Netting neutrophils in autoimmune small-vessel vasculitis
Authors:Kessenbrock, K.; Krumbholz, M.; Schönermarck, U.; Back, W.; Gross, W. L.; Werb, Z.; Gröne, H. J.; Brinkmann, V.; Jenne, D. E.
Language:English
Date of Publication (YYYY-MM-DD):2009-06
Title of Journal:Nature Medicine
Journal Abbrev.:Nat. Med.
Volume:15
Issue / Number:6
Start Page:623
End Page:625
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
MPI für Infektionsbiologie/Core Facilities
External Affiliations:[Kessenbrock, Kai; Werb, Zena] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA.; [Krumbholz, Markus] Univ Munich, Inst Clin Neuroimmunol, Munich, Germany.; [Schoenermarck, Ulf] Univ Hosp Grosshadern, Med Clin 1, Div Nephrol, Munich, Germany.; [Back, Walter] Univ Heidelberg, Mannheim Clin, Dept Pathol, D-6800 Mannheim, Germany.; [Gross, Wolfgang L.] Med Univ Lubeck, Univ Klinikum Schleswig Holstein, Vasculitis Ctr, Dept Rheumatol, D-23538 Lubeck, Germany.; [Gross, Wolfgang L.] Rheumaklin Bad Bramstedt, Lubeck, Germany.; [Groene, Hermann-Josef] German Canc Res Ctr, Dept Cellular & Mol Pathol, D-6900 Heidelberg, Germany.
Identifiers:ISI:000266731600020 [ID No:1]
ISSN:1078-8956 [ID No:2]
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