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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents

ID: 432455.0, MPI für Neurobiologie / Neuroimmunology
Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue
Authors:Pellkofer, H. L.; Voltz, R.; Goebels, N.; Hohlfeld, R.; Dornmair, K.
Date of Publication (YYYY-MM-DD):2009-05
Title of Journal:Archives of Neurology
Journal Abbrev.:Arch. Neurol.
Issue / Number:5
Start Page:655
End Page:658
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Background: According to established criteria, paraneoplastic encephalomyelitis with adrenal neuroblastoma comprises a definite paraneoplastic neurologic syndrome. Objective: To detect T-cell clones that cross-react against antigens shared between tumor and nervous system. Design: Case study. Setting: Academic research. Patient: A 22-year-old woman having paraneoplastic encephalomyelitis with adrenal neuroblastoma. Main Outcome Measures: We compared the T-cell receptor repertoires expressed in blood, cerebrospinal fluid, and neuroblastoma tumor tissue using complementary determining region 3 (CDR3) spectratyping and clone-specific polymerase chain reaction. Results: The T-cell receptor repertoire in cerebrospinal fluid was narrow compared with that in tumor and blood. Four T-cell clones from different tissues had identical T-cell receptor beta chains. Remarkably, the chains showed identical amino acid sequences but different nucleotide sequences. Conclusions: These T cells represent ontogenetically distinct clones but share functionally identical receptors. They recognize the same antigen in nervous system and tumor tissue and represent an attractive target for selective therapy.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)/Clinical Neuroimmunology (Hohlfeld)
External Affiliations:[Pellkofer, Hannah L.; Hohlfeld, Reinhard; Dornmair, Klaus] Univ Munich, Univ Hosp Grosshadern, Inst Clin Neuroimmunol, Munich, Germany.; [Voltz, Raymond] Univ Cologne, Univ Hosp, Dept Palliat Med, Cologne, Germany.; [Goebels, Norbert] Univ Zurich Hosp, Neurol Klin, CH-8091 Zurich, Switzerland.
Identifiers:ISI:000265993700015 [ID No:1]
ISSN:0003-9942 [ID No:2]
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