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          Institute: MPI für Dynamik komplexer technischer Systeme     Collection: Physical and Chemical Foundations of Process Engineering     Display Documents



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ID: 435956.0, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering
How to overcome limitations in biotechnological processes - examples from hydroxynitrile lyase applications
Authors:Andexer, J. N.; von Langermann, J.; Kragl, U.; Pohl, M.
Language:English
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Trends in Biotechnology
Volume:27
Issue / Number:10
Start Page:599
End Page:607
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:During the last decades, enzymes became very versatile catalysts for a variety of reactions including natural and unnatural compounds. However, many enzyme-catalysed reactions suffer from diverse restrictions because of limitations related to process parameters or the enzyme. The understanding and overcoming of those undesired side effects is therefore mandatory for the implementation of optimal process parameters. To achieve this aim, various methods from molecular biology and reaction engineering can be employed. By focusing on the hydroxynitrile lyase-catalysed synthesis of enantiopure cyanohydrins, we give an overview of strategies to improve commercially utilized enzymes and to suppress non-enzymatic reactions. Particular emphasis is placed on the necessity to combine approaches from different fields, such as enzyme engineering and reaction engineering.
Copyright © 2009 Elsevier Ltd All rights reserved.
[accessed September 17, 2009]
External Publication Status:published
Document Type:Article
Communicated by:Andreas Seidel-Morgenstern
Affiliations:MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
External Affiliations:Universität Düsseldorf
Institut für Molekulare Enzymtechnologie
D-52426 Jülich, Germany

Universität Rostock
Institut für Chemie
Albert-Einstein-Str. 3a,
D-18059 Rostock, Germany

University of Cambridge
Department of Chemistry
Lensfield Road, Cambridge, CB2 1EW, United Kingdom
Identifiers:DOI:10.1016/j.tibtech.2009.07.005
LOCALID:24/09
URL:http://dx.doi.org/10.1016/j.tibtech.2009.07.005 [Publisher's Homepage]
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