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          Institute: MPI für Infektionsbiologie     Collection: Department of Immunology     Display Documents



  history
ID: 436553.0, MPI für Infektionsbiologie / Department of Immunology
Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis
Authors:Sun, Ronggai; Skeiky, Yasir A. W.; Izzo, Angelo; Dheenadhayalan, Veerabadran; Imam, Zakaria; Penn, Erica; Stagliano, Katherine; Haddock, Scott; Mueller, Stefanie; Fulkerson, John; Scanga, Charles; Grover, Ajay; Derrick, Steven C.; Morris, Sheldon; Hone, David M.; Horwitz, Marcus A.; Kaufmann, Stefan H. E.; Sadoff, Jerald C.
Language:English
Date of Publication (YYYY-MM-DD):2009-07
Title of Journal:Vaccine
Volume:27
Issue / Number:33
Start Page:4412
End Page:4423
Copyright:Copyright © 2009 Elsevier Ltd All rights reserved.
Review Status:not specified
Audience:Experts Only
Free Keywords:Recombinant BCG; Endosome lysis; Antigen over-expression; Ad35;; Prime-boost; Tuberculosis; Vaccination; T-cell; Protection; GUINEA-PIG MODEL; IMMUNODEFICIENCY-VIRUS-INFECTION; MAJOR SECRETORY; PROTEIN; CD8(+) T-CELLS; PULMONARY TUBERCULOSIS; IMMUNE-RESPONSES;; SUBUNIT VACCINE; INTERFERON-GAMMA; BOVIS BCG; EXTRACELLULAR PROTEINS
Comment of the Author/Creator:Acknowledgments
This study was supported by grants awarded to the Aeras Global TB Vaccine Foundation by the Bill and Melinda Gates Foundation and The Netherlands Ministry of Foreign Affairs (DGIS). Native Ag85 complex, Ag85A, Ag85B, CFP and whole cell lysate derived from Mtb were produced and provided by Drs. John Belisle and Karen Dobos at the Colorado State University under the TB Vaccine Testing and Research Material contract N01-A1-400091. We are grateful to Margaret Ann Goetz and James Zhou for statistical analysis, Dr. Lewellys Barker for critical review of the manuscript and Dr. Barbara Shepherd for editorial assistance.
External Publication Status:published
Document Type:Article
Communicated by:Hilmar Fünning
Affiliations:MPI für Infektionsbiologie/Department of Immunology
External Affiliations:Aeras Global TB Vaccine Foundation, 1405 Research Blvd., Rockville, MD 20850, USA; Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA; Center for Biologics Evaluation and Research, U.S. FDA, Bethesda, MD 20892, United States; UCLA School of Medicine, University of California, Los Angeles, CA 90095, United States.
Identifiers:ISSN:0264-410X %R 10.1016/j.vaccine.2009.05.048 [ID No:1]
ISI:000268217600005 [ID No:2]
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