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          Institute: MPI für Neurobiologie     Collection: Molecular Neurobiology     Display Documents



  history
ID: 437293.0, MPI für Neurobiologie / Molecular Neurobiology
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
Authors:Filosa, A.; Paixao, S.; Honsek, S. D.; Carmona, M. A.; Becker, L.; Feddersen, B.; Gaitanos, L.; Rudhard, Y.; Schoepfer, R.; Klopstock, T.; Kullander, K.; Rose, C. R.; Pasquale, E. B.; Klein, R.
Language:English
Date of Publication (YYYY-MM-DD):2009-10
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Volume:12
Issue / Number:10
Start Page:1285
End Page:1292
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Astrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to regulate neuron-glia interactions, and EphA4-mediated ephrin reverse signaling is required for synaptic plasticity in the hippocampus. Here we show that long-term potentiation (LTP) at the CA3-CA1 synapse is modulated by EphA4 in the postsynaptic CA1 cell and by ephrin-A3, a ligand of EphA4 that is found in astrocytes. Lack of EphA4 increased the abundance of glial glutamate transporters, and ephrin-A3 modulated transporter currents in astrocytes. Pharmacological inhibition of glial glutamate transporters rescued the LTP defects in EphA4 (Epha4) and ephrin-A3 (Efna3) mutant mice. Transgenic overexpression of ephrin-A3 in astrocytes reduces glutamate transporter levels and produces focal dendritic swellings possibly caused by glutamate excitotoxicity. These results suggest that EphA4/ephrin-A3 signaling is a critical mechanism for astrocytes to regulate synaptic function and plasticity.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Molecular Neurobiology (Klein)
External Affiliations:[Honsek, Silke D.; Rose, Christine R.] Univ Dusseldorf, Inst Neurobiol, Dusseldorf, Germany.; [Carmona, Maria A.; Pasquale, Elena B.] Burnham Inst Med Res, La Jolla, CA USA.; [Becker, Lore; Klopstock, Thomas] German Res Ctr Environm Hlth GmbH, German Mouse Clin, Inst Expt Genet, Helmholtz Ctr, Munich, Germany.; [Becker, Lore; Feddersen, Berend; Klopstock, Thomas] Univ Munich, Dept Neurol, Friedrich Baur Inst, D-8000 Munich, Germany.; [Rudhard, York; Schoepfer, Ralf] UCL, Mol Pharmacol Lab, London, England.; [Kullander, Klas] Uppsala Univ, Dept Neurosci, Uppsala, Sweden.
Identifiers:ISI:000270170200017 [ID No:1]
ISSN:1097-6256 [ID No:2]
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