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          Institute: MPI für Neurobiologie     Collection: Molecular Neurobiology     Display Documents

ID: 440939.0, MPI für Neurobiologie / Molecular Neurobiology
Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany
Authors:Luecking, C. B.; Lichtner, P.; Kramer, E. R.; Gieger, C.; Illig, T.; Dichgans, M.; Berg, D.; Gasser, T.
Date of Publication (YYYY-MM-DD):2010-01
Title of Journal:Neurobiology of Aging
Journal Abbrev.:Neurobiol. Aging
Issue / Number:1
Start Page:167
End Page:168
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The aetiology of the selective neurodegeneration in Parkinson's disease (PD) is still unknown. Neurotrophic factors, e.g. glial cell line-derived neurotrophic factor (GDNF), have been shown to promote-survival of dopaminergic neurons. Interestingly, aged mice lacking GDNF-receptor (RET) in their dopaminergic neurons show a phenotype similar to presymptomatic PD. We therefore were interested whether polymorphisms in the RET gene were associated with increased PD risk. Analyzing 25 SNPs in the RET region in 340 Southern German PD patients and 340 age- and sex-matched controls from Southern Germany (KORA S4), we did not find any significant association with PD, suggesting that the equilibrium of trophic factors in PD might be disturbed on other levels than the genomic encoding. (C) 2008 Elsevier Inc. All rights reserved.
Free Keywords:Ret; GDNF; Parkinson's disease; Genetic association
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Molecular Neurobiology (Klein)
External Affiliations:[Luecking, C. B.; Dichgans, M.] Univ Munich, Dept Neurol, D-81377 Munich, Germany.; [Lichtner, P.] GSF Natl Res Ctr Environm & Hlth, Inst Human Genet, D-85764 Neuherberg, Germany.; [Gieger, C.] GSF Natl Res Ctr Environm & Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany.; [Gieger, C.; Illig, T.] Univ Munich, Inst Med Informat Biometry & Epidemiol, D-85764 Neuherberg, Germany.; [Berg, D.; Gasser, T.] Univ Tübingen, Hertie Inst Clin Brain Res, D-72076 Tübingen, Germany.
Identifiers:ISI:000272213500019 [ID No:1]
ISSN:0197-4580 [ID No:2]
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