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          Institute: MPI für molekulare Genetik     Collection: Research Group Development and Disease     Display Documents



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ID: 456474.0, MPI für molekulare Genetik / Research Group Development and Disease
The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling
Authors:van Wijk, Nicole Verhey; Witte, Florian; Feike, Ann Carolin; Schambony, Alexandra; Birchmeier, Walter; Mundlos, Stefan; Stricker, Sigmar
Language:English
Date of Publication (YYYY-MM-DD):2009-12-11
Title of Journal:Biochemical and Biophysical Research Communications
Journal Abbrev.:Biochem Biophys Res Commun
Volume:390
Issue / Number:2
Start Page:211
End Page:216
Copyright:© 2009 Elsevier B.V.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Wtip is a LIM domain protein of the Ajuba/Zyxin family involved in kidney and neural crest development; Ror2 is a receptor tyrosine kinase involved in the development of skeleton, heart, lung, genitalia and kidneys. Here we describe Wtip as an intracellular interaction partner of Ror2. Full-length Ror2 recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo. We show that Wtip is able to inhibit canonical Wnt signalling in mammalian cells and in Xenopus embryos linking Wtip to a crucial developmental pathway.
Free Keywords:Wtip; Ror2; Brachydactyly; Wnt
Comment of the Author/Creator:email: strick_s@molgen.mpg.de
External Publication Status:published
Document Type:Article
Communicated by:Stefan Mundlos
Affiliations:MPI für molekulare Genetik
External Affiliations:Institute for Medical Genetics, University Medicine Charité, Berlin, Germany
Developmental Biology Unit, Biology Department, University of Erlangen–Nuremberg, Erlangen, Germany
Max Delbrück Center for Molecular Medicine, Berlin, Germany
Identifiers:ISSN:0006-291X
URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
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