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          Institute: MPI für molekulare Genetik     Collection: Ribosome Research Groups     Display Documents



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ID: 456814.0, MPI für molekulare Genetik / Ribosome Research Groups
Ribosomal proteins : role in ribosomal functions
Authors:Wilson, Daniel N.; Gupta, Romi; Mikolajka, Aleksandra; Nierhaus, Knud H.
Language:English
Date of Publication (YYYY-MM-DD):2009-09-15
Title of Journal:Encyclopedia of Life Sciences
Volume:2009
Start Page:10
End Page:10
Copyright:© 2009 John Wiley & Sons, Ltd.
Review Status:not specified
Audience:Experts Only
Abstract / Description:The assignment of specific ribosomal functions to individual ribosomal proteins is difficult due to the enormous cooperativity of the ribosome; however, important roles for distinct ribosomal proteins are becoming evident. Although ribosomal ribonucleic acid (rRNA) has the major claim to certain aspects of ribosome function, such as decoding and peptidyltransferase activity, there are also protein-dominated functional hot-spots on the ribosome such as the messenger RNA (mRNA) entry pore, the translation factor-binding site and the exit of the ribosomal tunnel. The latter is binding site for both chaperones and complexes associated with protein transport through membranes. Furthermore, the contribution of ribosomal proteins is essential for the assembly and optimal functioning of the ribosome.
Free Keywords:rRNA-binding proteins; translational regulation; antitermination; antibiotic resistance; mutant proteins; binding of translational factors
External Publication Status:published
Document Type:Article
Communicated by:Ribosome Group
Affiliations:MPI für molekulare Genetik
External Affiliations:University of Munich, Munich, Germany
Identifiers:DOI:10.1002/9780470015902.a0000687.pub3
URL:http://mrw.interscience.wiley.com/emrw/97804700159...
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