Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Genetik     Collection: Ribosome Research Groups     Display Documents



  history
ID: 456824.0, MPI für molekulare Genetik / Ribosome Research Groups
Inhibitors of the elongation cycle of protein synthesis
Authors:Wilson, Daniel N.; Starosta, Agata L.; Yamamoto, Hiroshi; Nierhaus, Knud H.
Language:English
Date of Publication (YYYY-MM-DD):2009-09-15
Title of Journal:Encyclopedia of Life Sciences
Volume:2009
Start Page:13
End Page:13
Copyright:© 2009 John Wiley & Sons, Ltd.
Review Status:not specified
Audience:Experts Only
Abstract / Description:The protein synthetic machinery is a highly complex apparatus that offers many potential sites for functional interference and represents a major target in the cell for antibiotics. The knowledge of ribosomal structure and function has progressed enormously in recent years, which has, in turn, accelerated our understanding of the mechanism of drug action. Conversely, drugs have been used as tools to probe the translation cycle, thus providing a means to further dissect the multitude of steps involved in protein synthesis. In an era where bacteria are showing an ever-increasing resistance to many clinically relevant antibiotics, the importance of understanding their mechanism of inhibition is essential to the development of novel and more effective replacements.
Free Keywords:Antibiotics; Ribosomes; RNA; Antibiotic resistance
External Publication Status:published
Document Type:Article
Communicated by:Ribosome Group
Affiliations:MPI für molekulare Genetik
External Affiliations:University of Munich, Munich, Germany
Identifiers:DOI:10.1002/9780470015902.a0000550.pub2
URL:http://www.mrw.interscience.wiley.com/emrw/9780470...
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.