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          Institute: MPI für molekulare Genetik     Collection: Independent Junior Research Groups (Otto-Warburg-Laboratory)     Display Documents



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ID: 457100.0, MPI für molekulare Genetik / Independent Junior Research Groups (Otto-Warburg-Laboratory)
H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming
Authors:Daujat, Sylvain; Weiss, Thomas; Mohn, Fabio; Lange, Ulrike C.; Ziegler-Birling, Céline; Zeissler, Ulrike; Lappe, Michael; Schübeler, Dirk; Torres-Padilla, Maria-Elena; Schneider, Robert
Language:English
Date of Publication (YYYY-MM-DD):2009-07
Title of Journal:Nature Structural & Molecular Biology
Journal Abbrev.:Nature Struct & Mol Biol
Volume:16
Issue / Number:7
Start Page:777
End Page:781
Copyright:© 2009 Nature Publishing Group
Review Status:not specified
Audience:Experts Only
Abstract / Description:Histone modifications are central to the regulation of all DNA-dependent processes. Lys64 of histone H3 (H3K64) lies within the globular domain at a structurally important position. We identify trimethylation of H3K64 (H3K64me3) as a modification that is enriched at pericentric heterochromatin and associated with repeat sequences and transcriptionally inactive genomic regions. We show that this new mark is dynamic during the two main epigenetic reprogramming events in mammals. In primordial germ cells, H3K64me3 is present at the time of specification, but it disappears transiently during reprogramming. In early mouse embryos, it is inherited exclusively maternally; subsequently, the modification is rapidly removed, suggesting an important role for H3K64me3 turnover in development. Taken together, our findings establish H3K64me3 as a previously uncharacterized histone modification that is preferentially localized to repressive chromatin. We hypothesize that H3K64me3 helps to 'secure' nucleosomes, and perhaps the surrounding chromatin, in an appropriately repressed state during development.
Comment of the Author/Creator:email: schneiderr@immunbio.mpg.de
External Publication Status:published
Document Type:Article
Communicated by:OWL-Group
Affiliations:MPI für molekulare Genetik
External Affiliations:Max-Planck-Institute for Immunobiology, Freiburg, Germany
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, Strasbourg, France
Identifiers:DOI:10.1038/nsmb.1629
ISSN:1545-9993
URL:http://www.nature.com/nsmb/journal/v16/n7/pdf/nsmb...
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