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          Institute: Friedrich-Miescher-Laboratorium     Collection: Publikationen des FML     Display Documents



  history
ID: 458762.0, Friedrich-Miescher-Laboratorium / Publikationen des FML
Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin
Authors:Windecker, H.; Langegger, M.; Heinrich, S.; Hauf, S.
Language:English
Date of Publication (YYYY-MM-DD):2009-09
Title of Journal:EMBO Reports
Journal Abbrev.:EMBO Rep
Volume:10
Issue / Number:9
Start Page:1022
End Page:1028
Review Status:not specified
Audience:Experts Only
Abstract / Description:The eukaryotic spindle assembly checkpoint (SAC) delays anaphase in the presence of chromosome attachment errors. Bub3 has been reported to be required for SAC activity in all eukaryotes examined so far. We find that Bub3, unlike its binding partner Bub1, is not essential for the SAC in fission yeast. As Bub3 is needed for the efficient kinetochore localization of Bub1, and of Mad1, Mad2 and Mad3, this implies that most SAC proteins do not need to be enriched at the kinetochores for the SAC to function. We find that Bub3 is also dispensable for shugoshin localization to the centromeres, which is the second known function of Bub1. Instead, Bub3, together with Bub1, has a specific function in promoting the conversion from chromosome mono-orientation to bi-orientation.
Free Keywords:Cell Cycle Proteins/genetics/*metabolism; Chromosomal Proteins, Non-Histone/genetics/metabolism; Chromosome Segregation; Chromosomes, Fungal/*genetics/*metabolism; Mitotic Spindle Apparatus/metabolism; Protein Binding; Protein-Serine-Threonine Kinases/genetics/*metabolism; Schizosaccharomyces/genetics/*metabolism; Schizosaccharomyces pombe Proteins/genetics/*metabolism
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:Friedrich-Miescher-Laboratorium/Research Group Silke Hauf
External Affiliations:%G eng
Identifiers:ISSN:1469-3178 (Electronic) 1469-221X (Linking) %R embo... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:2]
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