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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents



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ID: 460665.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
Simultaneous alignment of short reads against multiple genomes
Authors:Schneeberger, K.; Hagmann, J.; Ossowski, S.; Warthmann, N.; Gesing, S.; Kohlbacher, O.; Weigel, D.
Date of Publication (YYYY-MM-DD):2009-09-17
Title of Journal:Genome Biol
Volume:10
Issue / Number:9
Start Page:R98
End Page:R98
Review Status:not specified
Audience:Not Specified
Abstract / Description:ABSTRACT: Genome resequencing with short reads generally relies on alignments against a single reference. GenomeMapper supports simultaneous mapping of short reads against multiple genomes by integrating related genomes (e.g., individuals of the same species) into a single graph structure. It constitutes the first approach for handling multiple references, and introduces representations for alignments against complex structures. Demonstrated benefits include access to polymorphisms that cannot be identified by alignments against the reference alone. Download GenomeMapper at http://1001genomes.org.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
Identifiers:ISSN:1465-6914 (Electronic) %R gb-2009-10-9-r98 [pii] 1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:2]
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