Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für biologische Kybernetik     Collection: Biologische Kybernetik     Display Documents



ID: 461628.0, MPI für biologische Kybernetik / Biologische Kybernetik
Influence of Different Assignment Conditions on the Determination of Symmetric Homo-dimeric Structures with ARIA
Authors:Bardiaux, B.; Bernard, A.; Rieping, W.; Habeck, M.; Malliavin, T.E.; Nilges, M.
Date of Publication (YYYY-MM-DD):2009-05
Title of Journal:Proteins
Volume:75
Issue / Number:3
Start Page:569
End Page:585
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:The ambiguous restraint for iterative assignment (ARIA) approach for NMR structure calculation is evaluated for symmetric homodimeric proteins by assessing the effect of several data analysis and assignment methods on the structure quality. In particular, we study the effects of network anchoring and spin-diffusion correction. The spin-diffusion correction improves the protein structure quality systematically, whereas network anchoring enhances the assignment efficiency by speeding up the convergence and coping with highly ambiguous data. For some homodimeric folds, network anchoring has been proved essential for unraveling both chain and proton assignment ambiguities.
External Publication Status:published
Document Type:Article
Communicated by:Holger Fischer
Affiliations:MPI für biologische Kybernetik/Empirical Inference (Dept. Schölkopf)
Identifiers:LOCALID:5384
URL:http://www3.interscience.wiley.com/cgi-bin/fulltex...
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.