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          Institute: MPI für biologische Kybernetik     Collection: Biologische Kybernetik     Display Documents



ID: 461687.0, MPI für biologische Kybernetik / Biologische Kybernetik
Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III)
Complexes of DO3A-Based Propylphosphonates
Authors:Mamedov, I.; Táborský, P.; Lubal, P.; Laurent, S.; Elst, L.; Mayer, H.A.; Logothetis, N.K.; Angelovski, G.
Date of Publication (YYYY-MM-DD):2009-08
Title of Journal:European Journal of Inorganic Chemistry
Volume:2009
Issue / Number:22
Start Page:3298
End Page:3306
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:Two DO3A-based ligands appended with the propylphosphonate side arm and their Ln3+ complexes were investigated. Proton relaxometric in vitro studies at 20 MHz and 60 MHz and 37 °C of the Gd3+ complex containing free acid exhibited relative changes of up to 56% in r1 relaxivity when the pH of the medium was changed from 4 to 7. This change is explained by the decrease in the number of coordinated water molecules from two to one. Temperature-dependent relaxivity and NMRD profiles of Gd3+ complexes showed a fast water exchange and a slightly increased rotational correlation time, which is characteristic of phosphonate-containing compounds. Thermodynamic and kinetic studies of the Gd3+ and Eu3+ complexes were performed by means of potentiometry and luminescence spectroscopy. The results indicate that the thermodynamic stability and kinetic inertness of these complexes are sufficient for their in vivo application.
External Publication Status:published
Document Type:Article
Communicated by:Holger Fischer
Affiliations:MPI für biologische Kybernetik/Neurophysiology (Dept. Logothetis)
Identifiers:LOCALID:5963
URL:http://www3.interscience.wiley.com/cgi-bin/fulltex...
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