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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2009 arch     Display Documents



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ID: 463161.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2009 arch
Growth, fluctuation and switching at microtubule plus ends
Authors:Howard, Jonathon; Hyman, Anthony A
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Nature Reviews. Molecular Cell Biology
Volume:10
Issue / Number:8
Start Page:569
End Page:574
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Recent experiments suggest that microtubules do not grow steadily but instead elongate at a rate that varies in time. We argue that this variation might arise from fluctuations in the length of a dynamic GTP-tubulin cap at the microtubule end. We propose that these fluctuations can lead to a switch in the dynamics of a microtubule end between growth and shrinkage, and provide insight into how the sensitivity of this switch can be changed by microtubule polymerases, such as XMAP215, and tensile forces, through the stabilization of initial contacts in the cap.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:n.n.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:1236
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