Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2009 arch     Display Documents



ID: 463179.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2009 arch
Control of convergent yolk syncytial layer nuclear movement in zebrafish
Authors:Carvalho, Lara; Stühmer, Jan; Bois, Justin S; Kalaidzidis, Yannis; Lecaudey, Virginie; Heisenberg, Carl-Philipp
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Development
Volume:136
Issue / Number:8
Start Page:1305
End Page:1315
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Nuclear movements play an essential role in metazoan development. Although the intracellular transport mechanisms underlying nuclear movements have been studied in detail, relatively little is known about signals from surrounding cells and tissues controlling these movements. Here, we show that, in gastrulating zebrafish embryos, convergence movements of nuclei within the yolk syncytial layer (YSL) are guided by mesoderm and endoderm progenitors migrating along the surface of the yolk towards the dorsal side of the developing gastrula. Progenitor cells direct the convergence movements of internal yolk syncytial nuclei (iYSN) by modulating cortical flow within the YSL in which the iYSN are entrained. The effect of mesoderm and endoderm progenitors on the convergence movement of iYSN depends on the expression of E-cadherin, indicating that adhesive contact between the cells and the YSL is required for the mesendoderm-modulated YSL cortical flow mediating nuclear convergence. In summary, our data reveal a crucial function for cortical flow in the coordination of syncytial nuclear movements with surrounding cells and tissues during zebrafish gastrulation.
External Publication Status:published
Document Type:Article
Communicated by:n.n.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:1288
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.