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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2009 arch     Display Documents



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ID: 463211.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2009 arch
4Alpha-bromo-5alpha-cholestan-3beta-ol and nor-5alpha-cholestan-3beta-ol derivatives-stereoselective synthesis and hormonal activity in Caenorhabditis elegans
Authors:Martin, Rene; Saini, Ratni; Bauer, Ingmar; Gruner, Margit; Kataeva, Olga; Zagoriy, Vyacheslav; Entchev, Eugeni V; Kurzchalia, Teymuras V; Knolker, Hans-Joachim
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Organic & Biomolecular Chemistry
Volume:7
Issue / Number:11
Start Page:2303
End Page:2309
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:We describe the stereoselective synthesis of 4alpha-bromo-5alpha-cholestan-3beta-ol, 21-nor-5alpha-cholestan-3beta-ol, 27-nor-5alpha-cholestan-3beta-ol and 21,27-bisnor-5alpha-cholestan-3beta-ol. In order to clarify the in vivo metabolism of cholesterol, these compounds have been used for feeding experiments in Caenorhabditis elegans. Our preliminary results provide important insights into the metabolism of cholesterol in worms.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:n.n.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:1334
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