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          Institute: MPI für terrestrische Mikrobiologie     Collection: Department-independent groups     Display Documents

ID: 463329.0, MPI für terrestrische Mikrobiologie / Department-independent groups
SulfoSYS (Sulfolobus Systems Biology): towards a
silicon cell model for the central carbohydrate
metabolism of the archaeon Sulfolobus
solfataricus under temperature variation
Authors:Albers, S.; Birkeland, N.; Driessen, A. J.; Gertig, S.; Haferkamp, P.; Klenk, H.; Kouril, T.; Manica, A.; Pham, T.; Ruoff, P.; Schleper, C.; Schomburg, D.; Sharkey, K.; Siebers, B.; Sierocinski, P.; Steuer, R.; Van der Oost, J.; Westehoff, H.; Wieloch, P.; Wright, P.; Zaparty, M.
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Biochemical Society Transactions
Start Page:58
End Page:64
Review Status:not specified
Audience:Not Specified
Abstract / Description:SulfoSYS (Sulfolobus Systems Biology) focuses on the study of the CCM (central carbohydrate metabolism)
of Sulfolobus solfataricus and its regulation under temperature variation at the systems level. In Archaea,
carbohydrates are metabolized by modifications of the classical pathways known from Bacteria or Eukarya,
e.g. the unusual branched ED (Entner–Doudoroff) pathway, which is utilized for glucose degradation
in S. solfataricus. This archaeal model organism of choice is a thermoacidophilic crenarchaeon that
optimally grows at 80◦C (60–92◦C) and pH 2–4. In general, life at high temperature requires very efficient
adaptation to temperature changes, which is most difficult to deal with for organisms, and it is unclear how
biological networks can withstand and respond to such changes. This integrative project combines genomic,
transcriptomic, proteomic and metabolomic, as well as kinetic and biochemical information. The final goal of
SulfoSYS is the construction of a silicon cell model for this part of the living cell that will enable computation
of the CCM network. In the present paper, we report on one of the first archaeal systems biology projects.
Free Keywords:central carbohydrate metabolism, crenarchaeon, silicon cell model, Sulfolobus solfataricus, systems biology, temperature variation.
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für terrestrische Mikrobiologie/Department-independent groups
External Affiliations:Department of Biology, University of Bergen, Jahnebakken 5, 5020 Bergen, Norway, ‡Department of Microbiology, Groningen
Biomolecular Sciences and Biotechnology
Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

Department of Bioinformatics and Systems Biology, Technical University Braunschweig, Langer Kamp 19b, Braunschweig 38106, Germany

Department of Chemistry, Biofilm Centre, Molecular Enzyme Technology and Biochemistry, University of Duisburg-Essen, Lotharstrasse, 47057 Duisburg, Germany

¶e.gene Biotechnologie GmbH, Poeckinger Fussweg 7a, 82340
Feldafing, Germany, **Department of Genetics in Ecology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria, ††Biological and Environmental
Systems Group, Department of Chemical and Process Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, U.K.

‡‡Department of Mathematics and Natural Science, University of Stavanger, Kristine Bonnevies vei 30, 4036 Stavanger, Norway, §§Manchester Centre for Integrative Systems
Biology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.,

Laboratory of Microbiology, Wageningen University, Hesselink van Suchtelenweg 4, 6703 CT Wageningen, The Netherlands, and ¶¶Netherlands Institute for Systems Biology, Free University Amsterdam, Kruislaan 318,
1098SM Amsterdam The Netherlands
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