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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 473389.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
GABA release from cerebellar stellate cells is developmentally regulated by presynaptic GABAB receptors in a target−cell−specific manner
Translation of Title:GABA release from cerebellar stellate cells is developmentally regulated by presynaptic GABA<sub>B</sub> receptors in a target−cell−specific manner
Authors:Astori, Simone; Luján, Rafael; Köhr, Georg
Language:English
Date of Publication (YYYY-MM-DD):2009-08-07
Title of Journal:European Journal of Neuroscience
Journal Abbrev.:Eur. J. Neurosci.
Volume:30
Issue / Number:4
Start Page:551
End Page:559
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Transmitter release from boutons along a common axon is often regulated depending on the postsynaptic target. Here, GABA
release from cerebellar stellate cells onto Purkinje cells and other stellate cells was examined in acute cerebellar slices of 2− and 4−
week−old mice. Consistent with previous findings on action potential−dependent GABA release, we found a developmental decrease
in inhibitory inputs onto Purkinje cells but not onto stellate cells when recording miniature inhibitory postsynaptic currents (mIPSCs).
Although amplitudes of mIPSCs were developmentally reduced in both cell types, mIPSC frequencies were decreased in Purkinje
cells but were increased in stellate cells. Similarly, modulation of GABA release by presynaptic GABAB receptors changed during
development in Purkinje cells but not in stellate cells, as demonstrated by the baclofen−mediated depression of mIPSC frequency and
evoked IPSC (eIPSC) amplitudes. The selectively diminished baclofen effect in 4−week−old Purkinje cells correlated with a selective
downregulation of presynaptic GABAB receptors at stellate cell−to−Purkinje cell synapses observed by immunoelectron microscopy
analysis. Thus, expression of GABAB receptors in stellate cell axons and presynaptic modulation of GABA release appear to change
during development in a target−cell−specific manner.
Free Keywords:baclofen, immunogold labelling, miniature current, presynaptic receptor, Purkinje cell
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Identifiers:LOCALID:7502
URI:http%3A%2F%2Fwww3.interscience.wiley.com%2Fcgi-bin...
URI:http%3A%2F%2Fwww3.interscience.wiley.com%2Fcgi-bin...
URI:http%3A%2F%2Fwww3.interscience.wiley.com%2Fjournal...
DOI:10.1111%2Fj.1460-9568.2009.06856.x
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