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          Institute: MPI für molekulare Genetik     Collection: Department of Human Molecular Genetics     Display Documents



  history
ID: 473578.0, MPI für molekulare Genetik / Department of Human Molecular Genetics
Essential role of glucose transporter GLUT3 for post-implantation embryonic development
Authors:Schmidt, S.; Hommel, A.; Gawlik, V.; Augustin, R.; Junicke, N.; Florian, S.; Richter, M.; Walther, D. J.; Montag, D.; Joost, H.-G.; Schürmann, A.
Language:English
Date of Publication (YYYY-MM-DD):2009-01
Title of Journal:Journal of Endocrinology
Journal Abbrev.:J Endocrinol
Volume:200
Issue / Number:1
Start Page:23
End Page:33
Copyright:© 2009 Society for Endocrinology
Review Status:not specified
Audience:Experts Only
Abstract / Description:Deletion of glucose transporter gene Slc2a3 (GLUT3) has previously been reported to result in embryonic lethality. Here, we define the exact time point of growth arrest and subsequent death of the embryo. Slc2a3–/– morulae and blastocysts developed normally, implanted in vivo, and formed egg-cylinder-stage embryos that appeared normal until day 6.0. At day 6.5, apoptosis was detected in the ectodermal cells of Slc2a3–/– embryos resulting in severe disorganization and growth retardation at day 7.5 and complete loss of embryos at day 12.5. GLUT3 was detected in placental cone, in the visceral ectoderm and in the mesoderm of 7.5-day-old wild-type embryos. Our data indicate that GLUT3 is essential for the development of early post-implanted embryos.
Comment of the Author/Creator:email: schuermann@dife.de
External Publication Status:published
Document Type:Article
Communicated by:Hans-Hilger Ropers
Affiliations:MPI für molekulare Genetik
External Affiliations:Departments of Pharmacology Toxicology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany
Research Group Neurogenetics, Leibniz-Institute for Neurobiology, D-39118 Magdeburg, Germany
Identifiers:DOI:10.1677/JOE-08-0262
ISSN:0022-0795
URL:http://joe.endocrinology-journals.org/cgi/reprint/...
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