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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents



ID: 474485.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
Stabilization of aerosolizable nano-carriers by freeze-drying
Authors:Packhaeuser, C. B.; Lahnstein, K.; Sitterberg, J.; Schmehl, T.; Gessler, T.; Bakowsky, U.; Seeger, W.; Kissel, T.
Date of Publication (YYYY-MM-DD):2009
Title of Journal:Pharm Res
Volume:26
Issue / Number:1
Start Page:129
End Page:38
Audience:Not Specified
Abstract / Description:PURPOSE: This study investigates the feasibility of freeze-drying aerosolizable nano-carriers (NC) by the use of different lyoprotective agents (LPA) and the influence of the freeze-drying on the physicochemical properties of these nano-carriers and on their aerosolization. METHODS: Nano-carriers were prepared from fast-degrading polymers, DMAPA(24)-PVAL-g-PLGA(1:7.5) and DEAPA(26)-PVAL-g-PLGA(1:10), and freeze-dried using increasing concentrations of different LPA. The hydrodynamic diameter, zeta potential and morphology (atomic force microscopy) of NC were characterized before and after freeze-drying. The ability to aerosolize using a jet nebulizer and an electronic micro-pump nebulizer was also investigated. RESULTS: Freeze-drying with LPA led to a decreased zeta-potential of NC and changes in size about 20 nm without alteration in shape, whereas lyophilizates without LPA were found to aggregate. While freeze-drying was positively affected by increasing concentrations, it was not influenced by the type of LPA. The possibility for aerosolization was not influenced by any LPA. CONCLUSIONS: Freeze-drying with LPA is a suitable method to physically stabilize fast-degrading NC from aqueous suspensions without influencing the aerosolizability.
Free Keywords:Aerosols; Arsenicals; Drug Carriers/*chemistry; Electrochemistry; Excipients; Freeze Drying; Lactic Acid; Laser-Doppler Flowmetry; Microscopy, Atomic Force; Nanoparticles/*chemistry; Nebulizers and Vaporizers; Particle Size; Polyglactin 910/analogs & derivatives; Polyglycolic Acid; Polymers/chemistry; Polyvinyl Alcohol; Suspensions; Viscosity
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
External Affiliations:Department of Pharmaceutics and Biopharmacy, Philipps-University, Ketzerbach 63, 35032, Marburg, Germany.
Identifiers:ISSN:0724-8741 (Print) 0724-8741 (Linking)
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=..
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