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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary ecology     Display Documents



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ID: 478387.0, MPI für Evolutionsbiologie / Evolutionary ecology
Reproductive fitness advantage of BCR-ABL expressing leukemia cells.
Authors:Traulsen, Arne; Pacheco, Jorge M.; Dingli, David
Language:English
Date of Publication (YYYY-MM-DD):2010-08-01
Title of Journal:Cancer Letters
Volume:294
Issue / Number:1
Start Page:43
End Page:48
Review Status:not specified
Audience:Not Specified
Abstract / Description:Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. We utilize a model of chronic myeloid leukemia (CML), to quantitate the fitness advantage conferred by expression of BCR-ABL in hematopoietic cells from in vivo patient data. We show that BCR-ABL expression provides a high fitness advantage, which explains why this single mutation drives the chronic phase of CML.
Free Keywords:cancer evolution; oncogenes; mutation fitness; BCR-ABL; cancer dynamics
External Publication Status:published
Document Type:Article
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsökologie
MPI für Evolutionsbiologie/AG Evolutionstheorie
External Affiliations:Departamento de Matemática da Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal; ATP-Group, CMAF, Complexo Interdisciplinar, P-1649-003 Lisboa Codex, Portugal; Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
Identifiers:ISSN:0304-3835 (print) [ID-No:1]
ISSN:1872-7980 (online) [ID-No:2]
DOI:10.1016/j.canlet.2010.01.020 [ID-No:3]
LOCALID:2767/S 39099 [Listen-Nummer/S-Nummer]
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