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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents



  history
ID: 479818.0, MPI für Neurobiologie / Neuroimmunology
Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury
Authors:Derfuss, T.; Linington, C.; Hohlfeld, R.; Meinl, E.
Language:English
Date of Publication (YYYY-MM-DD):2010-08
Title of Journal:Journal of Molecular Medicine
Journal Abbrev.:J. Mol. Med.
Volume:88
Issue / Number:8
Start Page:753
End Page:761
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Multiple sclerosis is thought to be an autoimmune-mediated disease of the central nervous system. For many years, T-cells were regarded as the key players in the pathogenesis, and myelin of white matter was considered as the main victim. However, research during recent years showed a more complex picture. Besides T-cells, also B-cells, antibodies and the innate immunity contribute to the tissue damage. Modern imaging techniques and neuropathological examinations showed that not only myelin but also axons, cortical neurons and nodes of Ranvier are damaged. The autoimmune targets of this widespread injury are so far not known. The identification of the axo-glial proteins contactin-2 and neurofascin provides excellent examples how antibodies can induce axonal injury at the node of Ranvier and how T-cells can destruct cortical integrity. This review will discuss the pathogenic implications of an autoimmune response against these newly discovered antigens.
Free Keywords:Multiple sclerosis; Neurofascin; Contactin-2; Grey matter injury; Cortical lesions; Node of Ranvier
External Publication Status:published
Document Type:Article
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)/Clinical Neuroimmunology (Hohlfeld)
External Affiliations:[Linington, Chris] Univ Glasgow, Div Clin Neurosci, Glasgow G51 4TF, Lanark, Scotland.; [Derfuss, Tobias] Univ Erlangen Nurnberg, Dept Neurol, D-91054 Erlangen, Germany.; [Hohlfeld, Reinhard; Meinl, Edgar] Univ Munich, Inst Clin Neuroimmunol, D-81377 Munich, Germany.
Identifiers:ISI:000279685300003 [ID No:1]
ISSN:0946-2716 [ID No:2]
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