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          Institute: MPI für Neurobiologie     Collection: Systems and Computational Neurobiology     Display Documents



  history
ID: 493357.0, MPI für Neurobiologie / Systems and Computational Neurobiology
Visualizing retinotopic half-wave rectified input to the motion detection circuitry of Drosophila
Authors:Reiff, D. F.; Plett, J.; Mank, M.; Griesbeck, O.; Borst, A.
Language:English
Date of Publication (YYYY-MM-DD):2010-08
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Volume:13
Issue / Number:8
Start Page:973
End Page:978
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:In the visual system of Drosophila, photoreceptors R1-R6 relay achromatic brightness information to five parallel pathways. Two of them, the lamina monopolar cells L1 and L2, represent the major input lines to the motion detection circuitry. We devised a new method for optical recording of visually evoked changes in intracellular Ca2+ in neurons using targeted expression of a genetically encoded Ca2+ indicator. Ca2+ in single terminals of L2 neurons in the medulla carried no information about the direction of motion. However, we found that brightness decrements (light-OFF) induced a strong increase in intracellular Ca2+ but brightness increments (light-ON) induced only small changes, suggesting that half-wave rectification of the input signal occurs. Thus, L2 predominantly transmits brightness decrements to downstream circuits that then compute the direction of image motion.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Systems and Computational Neurobiology (Borst)
MPI für Neurobiologie/Systems and Computational Neurobiology (Borst)/Cellular Dynamics (Griesbeck)
Identifiers:ISI:000280400600016 [ID No:1]
ISSN:1097-6256 [ID No:2]
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