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          Institute: MPI für Neurobiologie     Collection: Behavioral Genetics     Display Documents

ID: 494597.0, MPI für Neurobiologie / Behavioral Genetics
Specific Dopaminergic Neurons for the Formation of Labile Aversive Memory
Authors:Aso, Y.; Siwanowicz, I.; Braecker, L.; Ito, K.; Kitamoto, T.; Tanimoto, H.
Date of Publication (YYYY-MM-DD):2010-08-24
Title of Journal:Current Biology
Journal Abbrev.:Curr. Biol.
Issue / Number:16
Start Page:1445
End Page:1451
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:A paired presentation of an odor and electric shock induces aversive odor memory in Drosophila melanogaster [1, 2]. Electric shock reinforcement is mediated by dopaminergic neurons [3-5], and it converges with the odor signal in the mushroom body (MB) [2, 6-8]. Dopamine is synthesized in similar to 280 neurons that form distinct cell clusters [9-11] and is involved in a variety of brain functions [9, 12-20]. Recently, one of the dopaminergic clusters (PPL1) that includes MB-projecting neurons was shown to signal reinforcement for aversive odor memory [21]. As each dopaminergic cluster contains multiple types of neurons with different projections and physiological characteristics [11, 20], functional understanding of the circuit for aversive memory requires cellular identification. Here, we show that MB-M3, a specific type of dopaminergic neurons in the PAM cluster, is preferentially required for the formation of labile memory. Strikingly, flies formed significant aversive odor memory without electric shock when MB-M3 was selectively stimulated together with odor presentation. In addition, we identified another type of dopaminergic neurons in the PPL1 cluster, MB-MP1, which can induce aversive odor memory. As MB-M3 and MB-MP1 target the distinct subdomains of the MB, these reinforcement circuits might induce different forms of aversive memory in spatially segregated synapses in the MB.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Annegret Cerny
Affiliations:MPI für Neurobiologie/Behavioral Genetics (Tanimoto)
External Affiliations:[Ito, Kei] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan.; [Kitamoto, Toshihiro] Univ Iowa, Dept Anesthesia, Iowa City, IA 52242 USA.; [Kitamoto, Toshihiro] Univ Iowa, Interdisciplinary Program Genet, Iowa City, IA 52242 USA.; [Kitamoto, Toshihiro] Univ Iowa, Interdisciplinary Program Neurosci, Iowa City, IA 52242 USA.
Identifiers:ISI:000281328800023 [ID No:1]
ISSN:0960-9822 [ID No:2]
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