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          Institute: MPI für Evolutionsbiologie     Collection: Research Group Evolutionary Theory     Display Documents



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ID: 499438.0, MPI für Evolutionsbiologie / Research Group Evolutionary Theory
Somatic mutations and the hierarchy of hematopoiesis
Authors:Traulsen, Arne; Pacheco, Jorge M.; Luzzatto, Lucio; Dingli, David
Language:English
Date of Publication (YYYY-MM-DD):2010-11
Title of Journal:BioEssays
Volume:32
Issue / Number:11
Start Page:1003
End Page:1008
Review Status:not specified
Audience:Not Specified
Abstract / Description:Clonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: BCR-ABL, characteristic of chronic myeloid leukemia; mutations of the PIG-A gene, characteristic of paroxysmal nocturnal hemoglobinuria; the V617F mutation in the JAK2 gene, characteristic of myeloproliferative diseases. The population frequencies of these three blood disorders fit well with a hierarchical model of hematopoiesis. The fate of any mutant clone will depend on the target cell and on the fitness advantage, if any, that the mutation confers on the cell. In general, we can expect that only a mutation in a hematopoietic stem cell will give long-term disease; the same mutation taking place in a cell located more downstream may produce just a ripple in the hematopoietic ocean.
Free Keywords:clonal evolution; hematopoietic stem cells; mutations; progenitor cells; stochastic dynamics
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Brigitte Lechner
Affiliations:MPI für Evolutionsbiologie/AG Evolutionstheorie
External Affiliations:Departamento de Matemática e Aplicações, Universidade do Minho, Braga, Portugal; ATP-group, CMAF, Complexo Interdisciplinar, Lisboa, Portugal; Istituto Toscano Tumori, Florence, Italy; Division of Hematology, Mayo Clinic, Rochester, MN, USA
Identifiers:ISSN:0265-9247 (print) [ID-No:1]
ISSN:1521-1878 (online) [ID-No:2]
DOI:10.1002/bies.201000025 [ID-No:3]
LOCALID:2785/S 39123 [Listen-Nummer/S-Nummer]
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