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          Institute: MPI für Polymerforschung     Collection: MPI Polymerforschung     Display Documents



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ID: 51071.0, MPI für Polymerforschung / MPI Polymerforschung
A polyphenylene dendrimer-detergent complex as a highly fluorescent probe for bioassays
Authors:Minard-Basquin, C.; Weil, T.; Hohner, A.; Rädler, Joachim O.; Müllen, Klaus
Language:English
Date of Publication (YYYY-MM-DD):2003-05-14
Title of Journal:Journal of the American Chemical Society
Journal Abbrev.:J. Am. Chem. Soc.
Volume:125
Issue / Number:19
Start Page:5832
End Page:5838
Review Status:not specified
Audience:Not Specified
Abstract / Description:The synthesis of a polyphenylene dendrimer carrying three perylenemonoimide dyes as well as one biotin group is presented. Due to the hydrophobic polyphenylene scaffold, this dendrimer is insoluble in water thus preventing investigations in aqueous media. However, the use of an appropriate detergent results in the formation of well-defined supramolecular dendrimer-detergent complexes being soluble in aqueous media. The dendrimer-detergent complexes have a constant hydrodynamic radius of 7.1 nm measured by light scattering and fluorescence correlation spectroscopy and exhibit a high stability in the presence of blood serum proteins. The specific binding of the dendrimer-detergent complexes carrying a single biotin group to the protein streptavidin is demonstrated using a magnetic bead assay.
Comment of the Author/Creator:Date: 2003, MAY 14
External Publication Status:published
Document Type:Article
Affiliations:MPI für Polymerforschung
Identifiers:ISI:000182769400057 [ID No:1]
ISSN:0002-7863 [ID No:2]
LOCALID:P-03-268
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