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          Institute: MPI für Neurobiologie     Collection: Molecular Neurobiology     Display Documents

ID: 522020.0, MPI für Neurobiologie / Molecular Neurobiology
Structural Long-Term Changes at Mushroom Body Input Synapses
Authors:Kremer, M. C.; Christiansen, F.; Leiss, F.; Paehler, M.; Knapek, S.; Andlauer, T. F. M.; Förstner, F.; Kloppenburg, P.; Sigrist, S. J.; Tavosanis, G.
Date of Publication (YYYY-MM-DD):2010-11-09
Title of Journal:Current Biology
Journal Abbrev.:Curr. Biol.
Issue / Number:21
Start Page:1938
End Page:1944
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:How does the sensory environment shape circuit organization in higher brain centers? Here we have addressed the dependence on activity of a defined circuit within the mushroom body of adult Drosophila. This is a brain region receiving olfactory information and involved in long-term associative memory formation [1]. The main mushroom body input region, named the calyx, undergoes volumetric changes correlated with alterations of experience [2-5]. However, the underlying modifications at the cellular level remained unclear. Within the calyx, the clawed dendritic endings of mushroom body Kenyon cells form microglomeruli, distinct synaptic complexes with the presynaptic boutons of olfactory projection neurons [6, 7]. We developed tools for high-resolution imaging of pre- and postsynaptic compartments of defined calycal microglomeruli. Here we show that preventing firing of action potentials or synaptic transmission in a small, identified fraction of projection neurons causes alterations in the size, number, and active zone density of the microglomeruli formed by these neurons. These data provide clear evidence for activity-dependent organization of a circuit within the adult brain of the fly.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Molecular Neurobiology (Klein)/Dendrite differentiation (Tavosanis)
MPI für Neurobiologie/Systems and Computational Neurobiology (Borst)
External Affiliations:[Christiansen, Frauke; Andlauer, Till F. M.; Sigrist, Stephan J.] Free Univ Berlin, Inst Biol, Dept Genet, D-14195 Berlin, Germany.; [Christiansen, Frauke; Andlauer, Till F. M.; Sigrist, Stephan J.] Charite, D-10117 Berlin, Germany.; [Paehler, Moritz; Kloppenburg, Peter] Univ Cologne, Cologne Bioctr, Ctr Mol Med, D-50674 Cologne, Germany.; [Andlauer, Till F. M.] Univ Wurzburg, Bioimaging Ctr, Deutsch Forsch Gemeinschaft Res Ctr Expt Biomed, Rudolf Virchow Ctr, D-97080 Wurzburg, Germany.
Identifiers:ISI:000284193900028 [ID No:1]
ISSN:0960-9822 [ID No:2]
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