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          Institute: MPI für Biophysik     Collection: Abt. Biophysikalische Chemie     Display Documents



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ID: 532781.0, MPI für Biophysik / Abt. Biophysikalische Chemie
Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit
Authors:Yonehara, Keisuke; Balint, Kamill; Noda, Masaharu; Nagel, Georg; Bamberg, Ernst; Roska, Botond
Language:English
Date of Publication (YYYY-MM-DD):2011-01-20
Title of Journal:Nature
Journal Abbrev.:Nature
Volume:469
Issue / Number:7330
Start Page:407
End Page:410
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Spatial asymmetries in neural connectivity have an important role in creating basic building blocks of neuronal processing. A key circuit module of directionally selective (DS) retinal ganglion cells is a spatially asymmetric inhibitory input from starburst amacrine cells. It is not known how and when this circuit asymmetry is established during development. Here we photostimulate mouse starburst cells targeted with channelrhodopsin-2 (refs 6–8) while recording from a single genetically labelled type of DS cell. We follow the spatial distribution of synaptic strengths between starburst and DS cells during early postnatal development before these neurons can respond to a physiological light stimulus, and confirmconnectivity by monosynaptically restricted trans-synaptic rabies viral tracing. We show that asymmetry develops rapidly over a 2-day period through an intermediate state in which random or symmetric synaptic connections have been established. The development of asymmetry involves the spatially selective reorganization of inhibitory synaptic inputs. Intriguingly, the spatial distribution of excitatory synaptic inputs from starburst cells is significantly more symmetric than that of the inhibitory inputs at the end of this developmental period. Our work demonstrates a rapid developmental switch from a symmetric to asymmetric input distribution for inhibition in the neural circuit of a principal cell.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Biophysik/Abteilung Biophysikalische Chemie
External Affiliations:Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland;
Division of Molecular Neurobiology, National Institute for Basic Biology, 444-8787 Okazaki,
Japan;
School of Life Science, The Graduate University for Advanced Studies, 444-8787 Okazaki, Japan;
Universität Würzburg, Botanik I, Julius-von-Sachs-Platz 2, 97082 Würzburg, Germany; Johann Wolfgang Goethe-Universität, Institut für Biophysikalische Chemie, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany.
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