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          Institute: MPI für Neurobiologie     Collection: Neuroimmunology     Display Documents

ID: 532890.0, MPI für Neurobiologie / Neuroimmunology
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Authors:Fitzner, D.; Schnaars, M.; van Rossum, D.; Krishnamoorthy, G.; Dibaj, P.; Bakhti, M.; Regen, T.; Hanisch, U. K.; Simons, M.
Date of Publication (YYYY-MM-DD):2011-02-01
Title of Journal:Journal of Cell Science
Journal Abbrev.:J. Cell Sci.
Issue / Number:3
Start Page:447
End Page:458
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The transfer of antigens from oligodendrocytes to immune cells has been implicated in the pathogenesis of autoimmune diseases. Here, we show that oligodendrocytes secrete small membrane vesicles called exosomes, which are specifically and efficiently taken up by microglia both in vitro and in vivo. Internalisation of exosomes occurs by a macropinocytotic mechanism without inducing a concomitant inflammatory response. After stimulation of microglia with interferon-gamma, we observe an upregulation of MHC class II in a subpopulation of microglia. However, exosomes are preferentially internalised in microglia that do not seem to have antigen-presenting capacity. We propose that the constitutive macropinocytotic clearance of exosomes by a subset of microglia represents an important mechanism through which microglia participate in the degradation of oligodendroglial membrane in an immunologically 'silent' manner. By designating the capacity for macropinocytosis and antigen presentation to distinct cells, degradation and immune function might be assigned to different subtypes of microglia.
Free Keywords:Macropinocytosis; Microglia; Myelin; Oligodendrocytes; Exosomes
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Affiliations:MPI für Neurobiologie/Neuroimmunology (Wekerle)
External Affiliations:[Fitzner, Dirk; Schnaars, Mareike; Bakhti, Mostafa; Simons, Mikael] Max Planck Inst Expt Med, D-37075 Gottingen, Germany.; [Schnaars, Mareike; Dibaj, Payam; Simons, Mikael] Univ Gottingen, Dept Neurol, D-37075 Gottingen, Germany.; [van Rossum, Denise; Regen, Tommy; Hanisch, Uwe-Karsten] Univ Gottingen, Inst Neuropathol, D-37075 Gottingen, Germany.
Identifiers:ISI:000286223600016 [ID No:1]
ISSN:0021-9533 [ID No:2]
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