MPI für molekulare Genetik / Department of Human Molecular Genetics |
|Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice.|
|Authors:||Peleg, Shahaf; Sananbenesi, Farahnaz; Zovoilis, Athanasios; Burkhardt, Susanne; Bahari-Javan, Sanaz; Agis-Balboa, Roberto Carlos; Cota, Perla; Wittnam, Jessica Lee; Gogol-Doering, Andreas; Opitz, Lennart; Salinas-Riester, Gabriella; Dettenhofer, Markus; Kang, Hui; Farinelli, Laurent; Chen, Wei; Fischer, André|
|Date of Publication (YYYY-MM-DD):||2010-05-07|
|Title of Journal:||Science|
|Issue / Number:||5979|
|Copyright:||© 2010 American Association for the Advancement of Science. All Rights Reserved.|
|Review Status:||not specified|
|Abstract / Description:||As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation. Restoration of physiological H4K12 acetylation reinstates the expression of learning-induced genes and leads to the recovery of cognitive abilities. Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain.|
|Comment of the Author/Creator:||To whom correspondence should be addressed.
|External Publication Status:||published|
|Communicated by:||Hans-Hilger Ropers|
|Affiliations:||MPI für molekulare Genetik|
|External Affiliations:||1.Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str. 5, D-37077 Goettingen, Germany;
2.Max Delbrueck Center for Molecular Medicine, Institute for Medical Systems Biology, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany;
3.DNA Microarray Facility, Georg August University, Humboldtallee 23, D-37073 Goettingen, Germany;
4.Harvard Medical School, Genetics Department, 77 Ave Louis Pasteur, Boston, MA 02115, USA;
5.Fasteris SA, CH-1228 Plan-les-Ouates, Switzerland.
|Sorry, no privileges||
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