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          Institute: MPI für Biophysik     Collection: Abt. Biophysikalische Chemie     Display Documents



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ID: 534142.0, MPI für Biophysik / Abt. Biophysikalische Chemie
Microbial rhodopsins in the spotlight
Authors:Bamann, Christian; Nagel, Georg; Bamberg, Ernst
Language:English
Date of Publication (YYYY-MM-DD):2010-10
Title of Journal:Current Opinion in Neurobiology
Journal Abbrev.:Curr. Opin. Neurobiol.
Volume:20
Issue / Number:5
Start Page:610
End Page:616
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:The discovery of the light-gated cation channel Channelrhodopsin-2 (ChR2) and the use of the rediscovered light-driven Cl-pump halorhodopsin (HR) as optogenetic tools — genetically encoded switches that enable neurons to be turned on or off with bursts of light — refines the functional study of neurons in larger networks. Cell-specific expression allows a fast optical scanning approach to determine neuronal crosstalk following plasticity at the single synapse level or longrange projections in locomotion and somatosensory networks. Both rhodopsins proved to work functionally and could evoke behavioral responses in lower model organisms, reinstall rudimentary visual perception in blind mice and were set in a biomedical context with the investigation of neurodegenerative diseases.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Biophysik/Abteilung Biophysikalische Chemie
External Affiliations:Johann Wolfgang Goethe-Universität, Institut für Biophysikalische Chemie, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany;
Universität Würzburg, Botanik I, Julius-von-Sachs-Platz 2, 97082 Würzburg, Germany
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