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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents

ID: 538375.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
TransFind--predicting transcriptional regulators for gene sets
Authors:Kielbasa, S. M.; Klein, H.; Roider, H. G.; Vingron, M.; Blüthgen, N.
Date of Publication (YYYY-MM-DD):2010-07-01
Title of Journal:Nucleic Acids Research
Journal Abbrev.:Nucleic Acids Res
Volume:38 Suppl
Start Page:W275
End Page:W280
Review Status:not specified
Audience:Experts Only
Abstract / Description:The analysis of putative transcription factor binding sites in promoter regions of coregulated genes allows to infer the transcription factors that underlie observed changes in gene expression. While such analyses constitute a central component of the in-silico characterization of transcriptional regulatory networks, there is still a lack of simple-to-use web servers able to combine state-of-the-art prediction methods with phylogenetic analysis and appropriate multiple testing corrected statistics, which returns the results within a short time. Having these aims in mind we developed TransFind, which is freely available at http://transfind.sys-bio.net/.
Free Keywords:Binding Sites; Gene Expression Regulation; Internet; Phylogeny; Promoter Regions, Genetic; Software; Transcription Factors/metabolism; Transcription, Genetic
External Publication Status:published
Document Type:Article
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:Institute of Pathology and Institute of Theoretical Biology, Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10115 Berlin, Germany
Identifiers:ISSN:1362-4962 (Electronic) [ID No:1]
DOI:doi:10.1093/nar/gkq438 [ID No:2]
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