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          Institute: MPI für molekulare Genetik     Collection: Research Group Development and Disease     Display Documents

ID: 539710.0, MPI für molekulare Genetik / Research Group Development and Disease
The 2nd Berlin BedRest Study: protocol and implementation
Authors:Belavy, D. L.; Bock, O.; Borst, H.; Armbrecht, G.; Gast, U.; Degner, C.; Beller, G.; Soll, H.; Salanova, M.; Habazettl, H.; Heer, M.; de Haan, A.; Stegeman, D. F.; Cerretelli, P.; Blottner, D.; Rittweger, J.; Gelfi, C.; Kornak, U.; Felsenberg, D.
Date of Publication (YYYY-MM-DD):2010-09-01
Title of Journal:Journal of Musculoskeletal and Neuronal Interaction
Journal Abbrev.:J Musculoskelet Neuronal Interact
Issue / Number:3
Start Page:207
End Page:219
Review Status:not specified
Audience:Experts Only
Abstract / Description:Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p < .0001), though similarly in all groups (p > or = .17). Body weight changes differed between groups (p < .0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVE-group displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest methodology are also discussed.
Free Keywords:Spaceflight;
Comment of the Author/Creator:Charité Universitatsmedizin Berlin,
Center of Muscle and Bone Research, Hindenburgdamm 30, 12203 Berlin, Germany.
External Publication Status:published
Document Type:Article
Communicated by:Stefan Mundlos
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Charité Universitätsmedizin Berlin, Center of Muscle and Bone Research, Hindenburgdamm 30, 12203 Berlin, Germany;
2.German Aerospace Center (DLR), Department of Aviation and Space Psychology, Sportallee 54a, 22335 Hamburg, Germany;
3.Charité Universitätsmedizin Berlin, Vegetative Anatomy and Center of Space Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany;
4.Charité Universitätsmedizin Berlin, Institute for Physiology, Arnimallee 22, 14195 Berlin, Germany;
5.German Aerospace Center (DLR), Institute of Aerospace Medicine and Space Physiology Linderhöhe, 51147 Köln, Germany;
6.Faculty of Human Movement Sciences, Research Institute MOVE, VU University, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands;
7.Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Department of Clinical Neurophysiology, 6500HB Nijmegen, The Netherlands;
8.Institute of Molecular Bioimaging and Physiology (IBFM), Palazzo LITA, via Fratelli Cervi 93, 20090 Segrate, Milano, Italy;
9.Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, M1 5GD, England;
10.University of Milano, Dept. Sciences and Biomedical Technologies, Via F.lli Cervi 93, 20090 Segrate, Milano, Italy;
11.Charité Universitätsmedizin Berlin, Center of Gynecology, Perinatal, Pediatric and Adolescent Medicine, Augustenburger Platz 1, 13353 Berlin, Germany.
Identifiers:ISSN:1108-7161 [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/20811145 [ID No:2]
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