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          Institute: MPI für molekulare Genetik     Collection: Research Group Development and Disease     Display Documents

ID: 541911.0, MPI für molekulare Genetik / Research Group Development and Disease
Impairment of Sox9 expression in limb buds of rats homozygous for hypodactyly mutation.
Authors:Liska, F.; Snajdr, P.; Stricker, S.; Gosele, C.; Krenova, D.; Mundlos, S.; Hubner, N.
Research Context:This work was partially supported by the Czech Science Foundation
Date of Publication (YYYY-MM-DD):2010-01-01
Title of Journal:Folia Biologica
Journal Abbrev.:Folia Biol (Praha)
Issue / Number:2
Start Page:58
End Page:65
Copyright:© 2010 Folia Biologica. Všechna práva vyhrazena.
Review Status:not specified
Audience:Experts Only
Abstract / Description:Rat hypodactyly (hd) is an autosomal recessive mutation manifesting in homozygotes as reduction or loss of digits II and III. We mapped the hd allele to a short segment of chromosome 10, containing 16 genes. None of these genes has been shown to influence limb development yet. In situ hybridization showed no changes in several important patterning genes (Shh, Fgf8, Bmp2, 4, 7). However, we found that expression of cartilage condensation marker Sox9, and Bmp receptor Bmpr1b (acting as an upstream activator of Sox9 expression) is absent from the subepithelial mesenchyme of the digit condensations II and III. The failure of the chondrogenic condensations to extend towards the subepithelial mesenchyme may reduce the size of digit primordia and underlie the subsequent loss of phalanges and reduction of metacarpals/metatarsals in hd rats.
Free Keywords:limb development
Bmp signaling
the Norway rat
Comment of the Author/Creator:Corresponding author: František Liška, Charles University in
Prague, First Faculty of Medicine, Institute of Biology and Medical
Genetics, Albertov 4, 128 00 Prague 2, Czech Republic.
Phone: +420 224 968 154; Fax: +420 224 918 666; e-mail: frantisek.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Stefan Mundlos
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Charles University in Prague, First Faculty of Medicine: Institute of Biology and Medical Genetics;
2.Institute of Anatomy, Prague, Czech Republic
3.Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.
Identifiers:ISSN:0015-5500 [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/20492757 [ID No:2]
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