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          Institute: MPI für Physik     Collection: MPI für Physik     Display Documents



ID: 544584.0, MPI für Physik / MPI für Physik
Imaging performance of a DEPFET pixel Bioscope system in Tritium autoradiography
Authors:Ulrici, J.; Fischer, P.; Klein, P.; Lutz, G.; Neeser, W.; Richter, R.; Strüder, L.; Trimpl, M.; Wermes, N.
Date of Publication (YYYY-MM-DD):2004
Title of Journal:Nuclear Instruments and Methods in Physics Research Section A
Journal Abbrev.:Nucl.Instrum.Meth.A
Issue / Number:547
Start Page:424
End Page:436
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:A Bioscope system based on a 64 _ 64-matrix of DEPFET pixels has been developed for real-time digital
autoradiography in biomedical applications. It provides very good energy and spatial resolution at the same time. The
DEPFET pixel cells consist of p-channel JFETs integrated into the high-ohmic n-silicon substrate. This leads to a very
low noise performance at room temperature. Two dedicated ASIC chips have been developed for steeringand readout
of the pixel matrix. The measured system noise of ð69 _ 4Þ e_ at 35 _C is mostly due to sensor leakage current and can be
largely reduced by cooling or a faster readout. The spatial resolution is examined by measurements with a laser as well
as with a dedicated test chart and is determined to be ð6:7 _ 0:7Þ mm for 6 keV-X-rays and 4:3 _ 0:8 mm for 22 keV-Xrays.
The measurements are compared to simulation results with different reconstruction algorithms. Due to the thin
entrance window at the detector backside and the low noise performance, a detection of low-energy b-emitters such as
3H is possible. Measurements with 3H-labeled biological samples were taken. The ability of the DEPFET pixel Bioscope
to separate different radiolabels in the same sample is demonstrated by a measurement with 3H and 14C.
Classification / Thesaurus:Semiconductor Detectors
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Physik
Identifiers:LOCALID:MPP-2004-245
URL:http://publications.mppmu.mpg.de/?action=search&mp...
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