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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 545947.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
CKAMP44: A brain−specific protein attenuating short−term synaptic plasticity in the dentate gyrus
Translation of Title:CKAMP44: A brain−specific protein attenuating short−term synaptic plasticity in the dentate gyrus
Authors:von Engelhardt, Jakob; Mack, Volker; Sprengel, Rolf; Kavenstock, Netta; Li, Ka Wan; Stern−Bach, Yael; Smit, August B.; Seeburg, Peter H.; Monyer, Hannah
Language:English
Date of Publication (YYYY-MM-DD):2010-02-25
Title of Journal:Science
Journal Abbrev.:Science
Volume:327
Issue / Number:5972
Start Page:1518
End Page:1522
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:CKAMP44, identified here by a proteomic approach, is a brain−specific type I transmembrane
protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus
oocytes reduced GluA1− and A2−mediated steady−state currents, but did not affect kainate− or
N−methyl−D−aspartate (NMDA) receptor−mediated currents. Mouse hippocampal CA1 pyramidal
neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger
and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction
in the paired−pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited
strong CKAMP44 expression, and CKAMP44 knockout increased the paired−pulse ratio of AMPA
currents in lateral and medial perforant path−granule cell synapses. CKAMP44 thus modulates
short−term plasticity at specific excitatory synapses.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Identifiers:LOCALID:7570
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcontent%2F327%2F...
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcontent%2F327%2F...
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcontent%2F327%2F...
DOI:10.1126%2Fscience.1184178
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