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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents

ID: 545964.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
An integrated genome research network for studying
the genetics of alcohol addiction
Translation of Title:An integrated genome research network for studying
the genetics of alcohol addiction
Authors:Spanagel, Rainer; Bartsch, Dusan; Brors, Bendikt; Dahmen, Norbert; Deussing, Jan; Eils, Roland; Ende, Gabriele; Gallinat, Jürgen; Gebicke−Haerter, Peter; Heinz, Andreas; Kiefer, Falk; Jäger, Willi; Mann, Karl; Matthäus, Franziska; Nöthen, Markus; Rietschel, Marcella; Sartorius, Alexander; Schütz, Günther; Sommer, Wolfgang H.; Sprengel, Rolf; Walter, Henrik; Wichmann, Erich; Wienker, Thomas; Wurst, Wolfgang; Zimmer, Andreas
Date of Publication (YYYY-MM-DD):2010-10-06
Title of Journal:Addiction Biology
Journal Abbrev.:Addiction Biology
Issue / Number:4
Start Page:369
End Page:379
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was
shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases,
including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome.
Alcoholism, which has been proven to have a high genetic load, is one potentially fatal consequence of chronic
heavy alcohol consumption, and may be regarded as one of the most prevalent neuropsychiatric diseases afflicting our
society today. The aim of the integrated genome research network ‘Genetics of Alcohol Addiction'−which is a German
inter−/trans−disciplinary life science consortium consisting of molecular biologists, behavioural pharmacologists,
system biologists with mathematicians, human geneticists and clinicians−is to better understand the genetics of
alcohol addiction by identifying and validating candidate genes and molecular networks involved in the aetiology of
this pathology. For comparison, addictive behaviour to other drugs of abuse (e.g. cocaine) is studied as well. Here, we
present an overview of our research consortium, the current state of the art on genetic research in the alcohol field,
and list finally several of our recently published research highlights. As a result of our scientific efforts, better insights
into the molecular and physiological processes underlying addictive behaviour will be obtained, new targets and target
networks in the addicted brain will be defined, and subsequently, novel and individualized treatment strategies for our
patients will be delivered.
Free Keywords:Alcoholism, drug addiction, genome−wide association study (GWAS), glutamate, imaging genetics, QTL analysis
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
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