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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 545965.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Encoding of conditioned fear in central
amygdala inhibitory circuits
Translation of Title:Encoding of conditioned fear in central
amygdala inhibitory circuits
Authors:Ciocchi, Stephane; Herry, Cyril; Grenier, François; Wolff, Steffen B. E.; Letzkus, Johannes J.; Vlachos, Ioannis; Ehrlich, Ingrid; Sprengel, Rolf; Deisseroth, Karl; Stadler, Michael B.; Müller, Christian; Lüthi, Andreas
Language:English
Date of Publication (YYYY-MM-DD):2010-11-10
Title of Journal:Nature
Journal Abbrev.:Nat.
Volume:468
Issue / Number:7321
Start Page:277
End Page:282
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The central amygdala (CEA), a nucleus predominantly composed of GABAergic inhibitory neurons, is essential for fear conditioning. How the acquisition and expression of conditioned fear are encoded within CEA inhibitory circuits is not
understood. Using in vivo electrophysiological, optogenetic and pharmacological approaches in mice, we show that neuronal activity in the lateral subdivision of the central amygdala (CEl) is required for fear acquisition, whereas conditioned fear responses are driven by output neurons in the medial subdivision (CEm). Functional circuit analysis
revealed that inhibitory CEA microcircuits are highly organized and that cell−type−specific plasticity of phasic and tonic activity in the CEl to CEm pathway may gate fear expression and regulate fear generalization. Our results define the functional architecture ofCEAmicrocircuits and their role in the acquisition and regulation of conditioned fear behaviour.
Free Keywords:Neuroscience, Physiology, Animal behaviour
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Identifiers:LOCALID:7619
URI:http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv...
URI:http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv...
URI:http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv...
DOI:10.1038%2Fnature09559
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