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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomolekulare Mechanismen     Display Documents



ID: 546009.0, MPI für medizinische Forschung / Abteilung Biomolekulare Mechanismen
Cryptotomography: Reconstructing 3D Fourier Intensities from Randomly Oriented Single−Shot Diffraction Patterns
Translation of Title:Cryptotomography: Reconstructing 3D Fourier Intensities from Randomly Oriented Single−Shot Diffraction Patterns
Authors:Loh, N. D.; Bogan, M. J.; Elser, V.; Barty, A.; Boutet, S.; Bajt, S.; Hajdu, J.; Ekeberg, T.; Maia, F. R.; Schulz, J.; Seibert, M. M.; Iwan, B.; Timneanu, N.; Marchesini, S.; Schlichting, Ilme; Shoeman, Robert L.; Lomb, Lukas; Frank, M.; Liang, M.; Chapman, H. N.
Language:English
Date of Publication (YYYY-MM-DD):2010-06-04
Title of Journal:Physical Review Letters
Journal Abbrev.:Phys. Rev. Lett.
Volume:104
Issue / Number:22
Start Page:65535
End Page:65535
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:We reconstructed the 3D Fourier intensity distribution of monodisperse prolate nanoparticles using single−shot 2D coherent diffraction patterns collected at DESY's FLASH facility when a bright, coherent, ultrafast x−ray pulse intercepted individual particles of random, unmeasured orientations. This first experimental demonstration of cryptotomography extended the expansion−maximization−compression framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter. This work is an important step towards realizing single−shot diffraction imaging of single biomolecules.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen
MPI für medizinische Forschung/Emeritus - Gruppe Organische Chemie
Identifiers:LOCALID:7650
URI:http%3A%2F%2Fprl.aps.org%2Fpdf%2FPRL%2Fv104%2Fi22%...
URI:http%3A%2F%2Fprl.aps.org%2Fabstract%2FPRL%2Fv104%2...
DOI:10.1103%2FPhysRevLett.104.225501
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