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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomolekulare Mechanismen     Display Documents

ID: 546010.0, MPI für medizinische Forschung / Abteilung Biomolekulare Mechanismen
Single−shot femtosecond x−ray diffraction from randomly oriented ellipsoidal nanoparticles
Translation of Title:Single−shot femtosecond x−ray diffraction from randomly oriented ellipsoidal nanoparticles
Authors:Bogan, M. J.; Boutet, S.; Barty, A.; Benner, W. H.; Frank, M.; Lomb, Lukas; Shoeman, Robert L.; Starodub, D.; Seibert, M. M.; Hau−Riege, S. P.; Woods, B.; Decorwin−Martin, P.; Bajt, S.; Schulz, J.; Rohner, U.; Iwan, B.; Timneanu, N.; Marchesini, S.; Schlichting, Ilme; Hajdu, J.; Chapman, H. N.
Date of Publication (YYYY-MM-DD):2010-09-14
Title of Journal:Phys. Rev. St Accel. Beams
Journal Abbrev.:Phys. Rev. ST Accel. Beams
Issue / Number:9
Start Page:65535
End Page:65535
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Coherent diffractive imaging of single particles using the single−shot "diffract and destroy" approach with an x−ray free electron laser (FEL) was recently demonstrated. A high−resolution low−noise coherent diffraction pattern, representative of the object before it turns into a plasma and explodes, results from the interaction of the FEL with the particle. Iterative phase retrieval algorithms are used to reconstruct two−dimensional projection images of the object from the recorded intensities alone. Here we describe the first single−shot diffraction data set that mimics the data proposed for obtaining 3D structure from identical particles. Ellipsoidal iron oxide nanoparticles (250??nm×50??nm) were aerosolized and injected through an aerodynamic lens stack into a soft x−ray FEL. Particle orientation was not controlled with this injection method. We observed that, at the instant the x−ray pulse interacts with the particle, a snapshot of the particle's orientation is encoded in the diffraction pattern. The results give credence to one of the technical concepts of imaging individual nanometer and subnanometer−sized objects such as single molecules or larger clusters of molecules using hard x−ray FELs and will be used to help develop robust algorithms for determining particle orientations and 3D structure.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen
MPI für medizinische Forschung/Emeritus - Gruppe Organische Chemie
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