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          Institute: MPI für medizinische Forschung     Collection: Max-Planck-Forschungsgruppe Neurophysiologie des Verhaltens (Andreas T. Schaefer)     Display Documents



ID: 546016.0, MPI für medizinische Forschung / Max-Planck-Forschungsgruppe Neurophysiologie des Verhaltens (Andreas T. Schaefer)
Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice
Translation of Title:Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice
Authors:Abraham, Nixon M.; Egger, Veronica; Shimshek, Derya R.; Renden, Robert; Fukunaga, Izumi; Sprengel, Rolf; Seeburg, Peter H.; Klugmann, Matthias; Margrie, Troy W.; Schaefer, Andreas T.; Kuner, Thomas
Language:English
Date of Publication (YYYY-MM-DD):2010-01-01
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:65
Issue / Number:3
Start Page:399
End Page:411
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Local inhibitory circuits are thought to shape neuronal information processing in the central nervous system, but it remains unclear how specific properties of inhibitory neuronal interactions translate into behavioral performance. In the olfactory bulb, inhibition of mitral/tufted cells via granule cells may contribute to odor discrimination behavior by refining neuronal representations of odors. Here we show that selective deletion of the AMPA receptor subunit GluA2 in granule cells boosted synaptic Ca2+ influx, increasing inhibition of mitral cells. On a behavioral level, discrimination of similar odor mixtures was accelerated while leaving learning and memory unaffected. In contrast, selective removal of NMDA receptors in granule cells slowed discrimination of similar odors. Our results demonstrate that inhibition of mitral cells controlled by granule cell glutamate receptors results in fast and accurate discrimination of similar odors. Thus, spatiotemporally defined molecular perturbations of olfactory bulb granule cells directly link stimulus similarity, neuronal processing time, and discrimination behavior to synaptic inhibition.
Free Keywords:SYSNEURO; MOLNEURO
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Nachwuchsgruppe Neurophysiologie des Verhaltens
Identifiers:LOCALID:7579
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%2FMia...
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fwww.cell.com%2Fneuron%2Fabstract%2FS0...
DOI:10.1016%2Fj.neuron.2010.01.009
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