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          Institute: MPI für medizinische Forschung     Collection: Arbeitsgruppe Witzemann / Koenen     Display Documents



ID: 546020.0, MPI für medizinische Forschung / Arbeitsgruppe Witzemann / Koenen
Voluntary Exercise Induces Anxiety−Like Behavior in Adult
C57BL/6J Mice Correlating With Hippocampal Neurogenesis
Translation of Title:Voluntary Exercise Induces Anxiety−Like Behavior in Adult
C57BL/6J Mice Correlating With Hippocampal Neurogenesis
Authors:Fuss, Johannes; Abdallah, Nada M.−B. Ben; Vogt, Miriam A.; Touma, Chadi; Pacifici, Pier Giorgio; Palme, Rupert; Witzemann, Veit; Hellweg, Rainer; Gass, Peter
Language:English
Date of Publication (YYYY-MM-DD):2010-03-01
Title of Journal:Hippocampus
Journal Abbrev.:Hippocampus
Volume:20
Issue / Number:3
Start Page:364
End Page:376
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Several studies investigated the effect of physical exercise
on emotional behaviors in rodents; resulting findings however remain
controversial. Despite the accepted notion that voluntary exercise alters
behavior in the same manners as antidepressant drugs, several studies
reported opposite or no effects at all. In an attempt to evaluate the
effect of physical exercise on emotional behaviors and brain plasticity,
we individually housed C57BL/6J male mice in cages equipped with a
running wheel. Three weeks after continuous voluntary running we
assessed their anxiety− and depression−like behaviors. Tests included
openfield, dark−light−box, elevated O−maze, learned helplessness, and
forced swim test. We measured corticosterone metabolite levels in feces
collected over a 24−h period and brain−derived neurotrophic factor
(BDNF) in several brain regions. Furthermore, cell proliferation and
adult hippocampal neurogenesis were assessed using Ki67 and Doublecortin.
Voluntary wheel running induced increased anxiety in the openfield,
elevated O−maze, and dark−light−box and higher levels of excreted
corticosterone metabolites. We did not observe any antidepressant
effect of running despite a significant increase of hippocampal neurogenesis
and BDNF. These data are thus far the first to indicate that the
effect of physical exercise in mice may be ambiguous. On one hand, the
running−induced increase of neurogenesis and BDNF seems to be irrelevant
in tests for depression−like behavior, at least in the present model
where running activity exceeded previous reports. On the other hand,
exercising mice display a more anxious phenotype and are exposed to
higher levels of stress hormones such as corticosterone. Intriguingly,
numbers of differentiating neurons correlate significantly with anxiety
parameters in the openfield and dark−light−box. We therefore conclude
that adult hippocampal neurogenesis is a crucial player in the genesis of
anxiety.
Free Keywords:wheel running; brain−derived neurotrophic factor
BDNF; corticosterone; hippocampus; depression
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Arbeitsgruppe Witzemann / Koenen
Identifiers:LOCALID:7537
URI:http%3A%2F%2Fwww3.interscience.wiley.com%2Fcgi-bin...
URI:http%3A%2F%2Fwww3.interscience.wiley.com%2Fjournal...
DOI:10.1002%2Fhipo.20634
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