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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomedizinische Optik     Display Documents

ID: 546037.0, MPI für medizinische Forschung / Abteilung Biomedizinische Optik
High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe
Translation of Title:High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe
Authors:Aguirre, A.D.; Sawinski, Jürgen; Huang, S. W.; Zhou, C.; Denk, Winfried; Fujimoto, J. G.
Date of Publication (YYYY-MM-DD):2010-03-01
Title of Journal:Optics Express
Journal Abbrev.:Optics express
Issue / Number:5
Start Page:4222
End Page:4239
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Optical coherence microscopy (OCM) is a promising technique for high resolution cellular imaging in human tissues. An OCM system for high−speed en face cellular resolution imaging was developed at 1060 nm wavelength at frame rates up to 5 Hz with resolutions of < 4 microm axial and < 2 microm transverse. The system utilized a novel polarization compensation method to combat wavelength dependent source polarization and achieve broadband electro−optic phase modulation compatible with ultrahigh axial resolution. In addition, the system incorporated an auto−focusing feature that enables precise, near real−time alignment of the confocal and coherence gates in tissue, allowing user−friendly optimization of image quality during the imaging procedure. Ex vivo cellular images of human esophagus, colon, and cervix as well as in vivo results from human skin are presented. Finally, the system design is demonstrated with a miniaturized piezoelectric fiber−scanning probe which can be adapted for laparoscopic and endoscopic imaging applications.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biomedizinische Optik
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